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Oral microorganisms are associated with systemic disease, and oral appliance are "reservoirs"
for these microorganisms (and these usually SMELL).
Because of this, oral appliances plaque may not only cause oral diesease(denture stomatitis,
periodontitis, and caries), but also may cause systemic disease (aspiration pneumonia,
gastrointestinal infection, and pleural infection). Therefore, sanitization through oral appliances
plaque control is necessary to prevent these diseases.

*Journal of American Dental association / The International Journal of Prosthodontics /
British Journal of Biomedical Science